Review
doi: 10.1016/s0887-7963(92)70155-2.
The impact of clotting factor concentrates on the immune system in individuals with hemophilia
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- PMID: 1348008
- DOI: 10.1016/s0887-7963(92)70155-2
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Review
The impact of clotting factor concentrates on the immune system in individuals with hemophilia
Transfus Med Rev.
1992 Jan.
Abstract
All reported studies to date, whether comparative or not, have shown a tendency toward a slower decrease in CD4+ numbers in patients receiving very high-purity agents with the rapidity in fall-off being affected by level of CD4+ numbers (low CD4+ numbers decreasing more rapidly), age (older persons showing more rapid CD4+ cell fall-off), and anti-HIV therapy. Clearly, these observations need to be extended in numbers, and the high-purity agents should also be similarly compared with the very high-purity therapies.
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