Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992;35(5):324-31.
doi: 10.1007/BF00189895.

Alleles of the rat T-cell receptor beta chain gene complex

E P Blankenhorn  1 , P D Smith, C B Williams, G A Gutman
Affiliations

Alleles of the rat T-cell receptor beta chain gene complex

E P Blankenhorn et al. Immunogenetics. 1992.

Abstract

Inbred rat strains provide a rich source of genetic diversity in immunologically relevant genes. We have characterized the alleles of one of these genes, encoding the rat T-cell receptor C beta 1 chain, by Southern blots and nucleic acid sequencing. The Cb1 gene segments from DA and LEW rats display complex allotypic variation: both coding and noncoding regions contain multiple nucleotide substitutions. In addition, there is a polymorphic insertion of a rat repetitive LINE element 3' to the coding region. The Cb1 alleles are one part of larger Tcrb haplotypes, containing V beta, D beta, and J beta elements; complete Cb1 genomic nucleotide sequences, and a partial list of the strain distribution of the two alleles, are described in this report.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Cell. 1984 Jul;37(3):1101-10 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Feb;86(3):988-92 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 May;82(9):2857-61 - PubMed
    1. Immunogenetics. 1985;21(2):135-42 - PubMed
    1. Clin Exp Immunol. 1989 Jul;77(1):21-4 - PubMed

Publication types

Substances