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. 1958 Jan 20;41(3):441-50.
doi: 10.1085/jgp.41.3.441.

Enzymic dephosphorylation of pepsin and pepsinogen

G E PERLMANN

Enzymic dephosphorylation of pepsin and pepsinogen

G E PERLMANN. J Gen Physiol. .

Abstract

It has been shown by the work presented in this paper that it is possible to dephosphorylate enzymically pepsin and pepsinogen with a variety of phosphatases. With the aid of a phosphodiesterase and the prostate phosphatase it has been established that the phosphorus in the two proteins is present as a diester and connects two sites of the peptide chain in a cyclic configuration. Removal of the phosphorus does not affect the proteolytic activity against hemoglobin or the synthetic substrate acetyl-L-phenylalanyl diiodotryosine, nor the pepsinogen pepsin transformation. However, an increase of the autodigestion of pepsin is observed.

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