Comparative Study
doi: 10.1007/BF00420977.
Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas
- PMID: 134920
- DOI: 10.1007/BF00420977
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Comparative Study
Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas
Diabetologia.
1976 Aug.
Abstract
In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, and glisoxepide, which were all alike in terms of the relationship between first and second phases of insulin release.
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