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Case Reports
. 1992 Mar;13(1-2):155-7.
doi: 10.1016/0169-328x(92)90056-h.

A dementing illness associated with a novel insertion in the prion protein gene

F Owen  1 , M Poulter, J Collinge, M Leach, R Lofthouse, T J Crow, A E Harding
Affiliations
Case Reports

A dementing illness associated with a novel insertion in the prion protein gene

F Owen et al. Brain Res Mol Brain Res. 1992 Mar.

Abstract

Following our previous report of an 144-bp insertion in the open reading frame of the prion protein (PrP) gene, we have now identified a larger, 216-bp, insertion in the gene. The insertion which is in frame encodes 9 extra octapeptide repeat sequences in addition to the 5 repeats normally present and represents the largest insertion so far detected in the PrP gene.

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