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. 1992;114(2):82-5.

[C-erbB-2 oncogene amplification in breast cancer in correlation to steroid and epidermal growth factor receptor]

[Article in German]
M Manavi  1 , K F Czerwenka, R Zeillinger, P Speiser, F Kury, U Steinhart, M Peschke, E Kubista, E Reinold
Affiliations
  • PMID: 1350129

[C-erbB-2 oncogene amplification in breast cancer in correlation to steroid and epidermal growth factor receptor]

[Article in German]
M Manavi et al. Zentralbl Gynakol. 1992.

Abstract

The amplification grade of oncogene c-erbB-2 was examined by the polymerase-chain-reaction-method in DNA's of 56 primary mammary carcinomas. 26 (46.4%) of these showed the amplified oncogene c-erbB-2. In the strongly amplified cases, the expression of the c-erbB-2 oncoprotein was verifiable immunohistochemically. Between the progesterone receptor status (PR) and the amplified c-erbB-2 oncogene there was a statistically proven dependency. No correlation was observed between the amplified c-erbB-2 oncogene and the epidermal growth-factor receptor (EGFR).

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