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Clinical Trial
. 1992 Feb;48(2):167-169.
doi: 10.1016/0304-3959(92)90054-F.

Enhancement of pentazocine analgesia by clonidine

Newton C Gordon  1 , Philip H Heller, Jon D Levine
Affiliations
Clinical Trial

Enhancement of pentazocine analgesia by clonidine

Newton C Gordon et al. Pain. 1992 Feb.

Abstract

Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain level when administered with intravenous placebo. When administered with pentazocine, clonidine caused a statistically significant increase in pentazocine analgesia. Comparison is made to other opiate-adrenergic interactions and possible mechanisms are discussed.

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