Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease
- PMID: 1350520
- DOI: 10.1161/01.cir.85.6.1973
Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease
Abstract
Background: Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the disorder.
Methods and results: Using this approach, we have identified linkage between a gene that causes the long QT syndrome and DNA markers on chromosome 11.
Conclusions: The identification of the chromosomal location of the long QT locus is the first step in defining the specific mutations that cause this disease.
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