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. 1992 May;45(5):416-9.
doi: 10.1136/jcp.45.5.416.

PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables

E Leonardi  1 , S Girlando, G Serio, F A Mauri, G Perrone, S Scampini, P Dalla Palma, M Barbareschi
Affiliations

PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables

E Leonardi et al. J Clin Pathol. 1992 May.

Abstract

Aims: To investigate the expression of two cell cycle related antigens (proliferating cell nuclear antigen (PCNA) and Ki67 related antigen) in a series of breast cancers; and the possible correlations between the PCNA and Ki67 labelling indexes (PCNA-LI and Ki67-LI) and their associations with other biological and clinicopathological variables.

Methods: Ninety six ductal and 10 lobular carcinoma specimens were investigated. Samples were fixed in formalin and in Methacarnoy for localisation of PCNA. Ki67 was immunostained on frozen sections. The PCNA-LI and Ki67-LI were evaluated in relation to tumour size, mitotic count, histological grade, nodal state as well as receptor content and altered expression of the p53 gene.

Results: PCNA-LI did not correlate with Ki67-LI, nor was it associated with any other variable examined. A high KI67-LI (above the median value of 13.5) was associated with high grade and mitotic count, negative receptor content, and altered expression of the p53 gene, but not with other variables.

Conclusions: The PCNA-LI does not seem to be a substitute for the Ki67-LI in evaluating the growth fraction in breast cancer.

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References

    1. J Histochem Cytochem. 1991 Jan;39(1):23-30 - PubMed
    1. Acta Neuropathol. 1991;81(6):675-9 - PubMed
    1. J Cell Sci. 1990 May;96 ( Pt 1):121-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7555-9 - PubMed
    1. Virchows Arch A Pathol Anat Histopathol. 1991;419(5):417-23 - PubMed