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. 1992;14(1-2):39-61.
doi: 10.3109/08923979209009212.

Effects of taxol on the macrophage function. Interactions with some immunological parameters

C Bottex-Gauthier  1 , F Condemine, F Picot, D Vidal
Affiliations

Effects of taxol on the macrophage function. Interactions with some immunological parameters

C Bottex-Gauthier et al. Immunopharmacol Immunotoxicol. 1992.

Abstract

The effects of Taxol on some immunological parameters were investigated, in vitro, in the murine macrophage cell line J774.1. Mitochondrial dehydrogenase activity and (3H) TdR incorporation were shown to be increased in Taxol treated cells. Likewise, Taxol induced TNF alpha secretion. But Taxol seemed to be a weak inducer of the two interleukins IL-1 and IL-2, since their detection occurred late in the cell culture supernatants.

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