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. 1976 Sep 15;54(18):881-7.
doi: 10.1007/BF01483590.

[Tryptophan-load in progressive scleroderma (author's transl)]

[Article in German]
H W Kreysel, K Meyerhoff, J Kimmig

[Tryptophan-load in progressive scleroderma (author's transl)]

[Article in German]
H W Kreysel et al. Klin Wochenschr. .

Abstract

This presentation describes effects of oral tryptophan loading (5.0 g DL) on tryptophan metabolism in healthy subjects (n = 10) and persons with progressive scleroderma. N1-methylnicotinamide (N1MN), 3-hydroxyanthranilic acid (3 HAA), kynurine (KN), tryptamin (TA), xantheurenic acid (XA) were determinated. Alterations of tryptophan metabolism were evaluated by 24 h urinary excretions of the following metabolites: 5-hydroxy indolacetic acid (5 HAA) and indole-3-acetic acid (IAA). The pathological pathways were discussed, especially the way and influence of serotonine.

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