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. 1992 Jun 27;339(8809):1570-1.
doi: 10.1016/0140-6736(92)91833-t.

Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity

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Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity

N G Burnet et al. Lancet. .

Abstract

The success of radiotherapy depends on the total radiation dose, which is limited by the tolerance of surrounding normal tissues. Since there is substantial variation among patients in normal-tissue radiosensitivity, we have tested the hypothesis that in-vitro cellular radiosensitivity is correlated with in-vitro normal-tissue responses. We exposed skin fibroblast cell lines from six radiation-treated patients to various doses of radiation and measured the proportions surviving. There was a strong relation between fibroblast sensitivity in vitro and normal-tissue reactions, especially acute effects. Assessment of radiosensitivity could lead to improved tumour cure rates by enabling radiation doses to be tailored to the individual.

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