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Review
. 1992 Jun 27;339(8809):1579-82.
doi: 10.1016/0140-6736(92)91840-5.

Cell migration, chimerism, and graft acceptance

T E Starzl  1 , A J Demetris, N Murase, S Ildstad, C Ricordi, M Trucco
Affiliations
Review

Cell migration, chimerism, and graft acceptance

T E Starzl et al. Lancet. .
No abstract available

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Figures

Fig 1
Fig 1. Heart (upper) and skin (lower) biopsy samples 33 months aftar liver transplantation
Immunoperoxidase stain with monoclonal antibody GSP5.3 that reacts with HLA-B7, which was present in the donor and not the recipient. Rust-coloured cells (numerous in heart. sparse in skin) are from donor (magnification × 500).
Fig 2
Fig 2. Chimerism after human liver transplantation
Southern blot analysis of polymerase chain reaction (PCR) products of liver (L), heart (H), and skin (S) 91 months after liver transplantation from HLA-DR1-specific and DRw52-associated amplification of the DRB1 gene in tissue biopsy samples. The presence of the donor DRB1 *0101 (donor-specific) allele in all three tissues was confirmed by hybridisation to a DRB-specific probe and by oligonucleotide probe subtyping of DR1-specific PCR products. M, molecular weight marker; N, PCR-negative control.
Fig 3
Fig 3. Result of traffic of donor and recipient Iymphoreticular cell traffic after successful liver transplantation
White, recipient cells; black, donor cells.
Fig 4
Fig 4. Reciprocai clonal expansion and depletion by immune cells in graft and recipient
HVG: host vs graft.
See this image and copyright information in PMC

Comment in

References

    1. Kashiwagi N, Porter KA, Penn I, Brettschneider L, Starzl TE. Studies of homograft sex and of gamma globulin phenotypes after orthotopic homotransplantation of the human liver. Surg Forum. 1969;20:374–76. - PMC - PubMed
    1. Porter KA. Pathology of the orthotopic homograft and heterograft. In: Starzl TE, editor. Experience in hepatic transplantation. WB Saunders; Philadelphia: 1969. pp. 464–65.
    1. Kashiwagi N. Special immunochemical studies. In: Starzl TE, editor. Experience in hepatic transplantation. WB Saunders; Philadelphia: 1969. pp. 394–407.
    1. Ramsey G, Nusbacher J, Starzl TE, Lindsay GD. Isohemagglutinins of graft origin after ABO-unmatched liver transplantation. N Engl J Med. 1984;311:1167–70. - PMC - PubMed
    1. Davies HFFS, Pollard SG, Calne RY. Soluble HLA antigens in the circulation of liver graft recipients. Transplantation. 1989;47:524–27. - PubMed

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