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. 1992 Feb 14;572(1-2):176-81.
doi: 10.1016/0006-8993(92)90467-n.

Hippocampal neuronal responsiveness to NMDA agonists and antagonists in the adult rat neonatally treated with MK-801

J A Gorter  1 , M Veerman, M Mirmiran
Affiliations

Hippocampal neuronal responsiveness to NMDA agonists and antagonists in the adult rat neonatally treated with MK-801

J A Gorter et al. Brain Res. .

Abstract

Long-lasting effects of neonatal interference with N-methyl-D-aspartate (NMDA) receptors were investigated by measuring responses to micro-iontophoretically applied NMDA agonists/antagonist in hippocampal neurons of the adult rat. Rat pups were chronically treated with MK-801 from postnatal day 8 through 19 and tested at postnatal day 70-100. CA1 cell responses to glutamate were not affected by the neonatal treatment. However, a stronger suppression of the NMDA evoked response by the NMDA site antagonist amino-5-phosphonovalerate (APV) was measured, suggesting a long-lasting configurational change of the NMDA receptor. The NMDA evoked responses were equally strong suppressed by MK-801 in both groups, suggesting that channel sites were not affected by this treatment.

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