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. 1958 Mar;13(1):44-51.
doi: 10.1111/j.1476-5381.1958.tb00188.x.

The renal removal of injected [14C] histamine from the blood in dogs

S E LINDELL, R W SCHAYER

The renal removal of injected [14C] histamine from the blood in dogs

S E LINDELL et al. Br J Pharmacol Chemother. 1958 Mar.

Abstract

The amounts of [(14)C]histamine in arterial blood, in renal venous blood and in urine during a steady intravenous infusion of [(14)C]histamine were measured in five anaesthetized dogs. The extraction ratio for [(14)C]histamine was 0.7 to 0.8, indicating that the histamine was efficiently taken up from the blood by the kidney. Only a small part (14 to 18%) of the [(14)C]histamine removed from the blood by the kidney appeared in the urine as histamine. Evidence was obtained that [(14)C]histamine was metabolized in the kidney not only by histaminase (diamine oxidase) but also by the histamine methylating enzyme.

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