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. 1958 Mar;13(1):62-4.
doi: 10.1111/j.1476-5381.1958.tb00191.x.

The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets

G V BORN, G I INGRAM, R S STACEY

The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets

G V BORN et al. Br J Pharmacol Chemother. 1958 Mar.

Abstract

In normal platelets a proportionality was found between the amount of adenosine triphosphate (ATP) and amount of 5-hydroxytryptamine (5-HT) in platelets both before and after incubating them in plasma to which 5-HT had been added. In patients receiving reserpine and in others with myeloid leukaemia, the amount of 5-HT in the platelets and the uptake of 5-HT by them were depressed, while the amount of ATP was normal. The possibility that ATP is involved in the accumulation of 5-HT by platelets is discussed.

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References

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