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. 1958 Mar;13(1):103-6.
doi: 10.1111/j.1476-5381.1958.tb00200.x.

Some pharmacological properties of murexine (urocanoylcholine)

M J KEYL, V P WHITTAKER

Some pharmacological properties of murexine (urocanoylcholine)

M J KEYL et al. Br J Pharmacol Chemother. 1958 Mar.

Abstract

Murexine (urocanoylcholine, [2-beta-imidazol-4(5)-ylacryloyloxyethyl] trimethylammonium bromide) has been shown to possess ganglion stimulating and neuromuscular blocking actions in cat, dog and rat. The blockade has been shown to be of the depolarizing type both on the basis of the resemblance of the pharmacological properties of the substance to that of known depolarizing blocking agents, and also directly by recording the depolarization produced in the endplate region of the gracilis muscle of the rat.

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