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. 1958 May 1;107(5):633-41.
doi: 10.1084/jem.107.5.633.

Adsorption and maturation of poliovirus in singly and multiply infected HeLa cells

J E DARNELL Jr

Adsorption and maturation of poliovirus in singly and multiply infected HeLa cells

J E DARNELL Jr. J Exp Med. .

Abstract

Studies with polio-infected HeLa cells using cell disruption techniques during the early stages of infection have shown that: The inoculum of poliovirus adsorbed on HeLa cells is largely inactivated. Infective virus accumulates in a monolayer sheet of cells in advance of release into the medium. The eclipse period is shorter in multiply infected cells than in those infected with a single particle.

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