The nature of antigen-antibody complexes formed in rabbits during an immune response to bovine serum albumin
- PMID: 13525577
- PMCID: PMC2136845
- DOI: 10.1084/jem.107.5.653
The nature of antigen-antibody complexes formed in rabbits during an immune response to bovine serum albumin
Abstract
The immune elimination of soluble BSA, following an intravenous injection, is accompanied by the appearance of circulating antigen-antibody complexes. The pattern of the appearance of circulating antigen-antibody complexes and the immune elimination of antigen probably depends on the amount of antigen injected, the rate of antibody synthesis, and perhaps, the quality of antibody produced. There is no relationship between the I* antigen-antibody complexes detected during the immune response in rabbits by ammonium sulfate precipitation and the material precipitated from immune sera as a result of treatment with alkali. Alkali-precipitable material present in the serum of rabbits at a time when I* antigen is also present contain at most only traces of the antigen.
Similar articles
-
Electron microscopic studies of experimental nephritis with ferritin-conjugated antibody. Localization of antigen-antibody complexes in rabbit glomeruli following repeated injections of bovine serum albumin.J Exp Med. 1963 Apr 1;117(4):691-704. doi: 10.1084/jem.117.4.691. J Exp Med. 1963. PMID: 14013043 Free PMC article.
-
STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS. I. STRUCTURAL STUDIES.J Exp Med. 1963 Oct 1;118(4):489-502. doi: 10.1084/jem.118.4.489. J Exp Med. 1963. PMID: 14067901 Free PMC article.
-
The mechanism of trapping of immune complexes in experimental antigen-induced arthritis.Rheumatology. 1975;6:288-92. Rheumatology. 1975. PMID: 128111
-
Biochemical aspects of immune complex formation and immune complex diseases.Allergy. 1980 Sep;35(6):457-72. doi: 10.1111/j.1398-9995.1980.tb01794.x. Allergy. 1980. PMID: 6451188 Review.
-
Studies of antigen-RNA and immunity.Mol Cell Biochem. 1979 Mar 5;24(1):45-62. doi: 10.1007/BF00220192. Mol Cell Biochem. 1979. PMID: 379590 Review. No abstract available.
Cited by
-
The cutaneous reaction to soluble antigen-antibody complexes; a comparison with the Arthus phenomenon.J Exp Med. 1958 Nov 1;108(5):591-604. doi: 10.1084/jem.108.5.591. J Exp Med. 1958. PMID: 13587844 Free PMC article.
-
The coexistence of antibody with antigen during immunological paralysis to BSA.Immunology. 1966 Dec;11(6):571-88. Immunology. 1966. PMID: 5954774 Free PMC article.
-
The fate of some alum-precipitated proteins after intramuscular injection.Immunology. 1963 Mar;6(2):179-88. Immunology. 1963. PMID: 13953216 Free PMC article.
-
The immune response of rabbits tolerant to bovine serum albumin to the injection of other heterologous serum albumins.J Exp Med. 1961 Jul 1;114(1):111-25. doi: 10.1084/jem.114.1.111. J Exp Med. 1961. PMID: 13783813 Free PMC article.
-
Elimination of 131-I-labelled protein antigens from the circulation of the mouse.Immunology. 1960 Oct;3(4):289-95. Immunology. 1960. PMID: 13724355 Free PMC article.
