doi: 10.1098/rspb.1992.0057.
Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa
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- PMID: 1352890
- DOI: 10.1098/rspb.1992.0057
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Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa
Proc Biol Sci.
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Abstract
We report the nucleotide sequence of eveC, a cnidarian eve-class homeobox; this is the first homeobox to be identified in any diploblastic organism, and is only the second eve-class in an invertebrate. Similarity between the predicted amino acid sequence of the eveC homeodomain and its insect and vertebrate equivalents was approximately 75-80% but, in the case of eveC, a role in segmentation can be ruled out. Our findings thus support the 'co-option' hypothesis: homeoboxes were an early feature of metazoan genomes, corresponding to the DNA-binding domains of more general transcription factors.
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