doi: 10.1007/978-3-0348-7262-1_23.
Study of the mechanism of prostacyclin (PgI2) action on myocardial contractility
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- PMID: 1352936
- DOI: 10.1007/978-3-0348-7262-1_23
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Study of the mechanism of prostacyclin (PgI2) action on myocardial contractility
Agents Actions Suppl.
1992.
Abstract
The experiments done on the isolated right ventricle of rat heart suspended in the bath for isolated organs with oxygenated Tyrode's solution showed the PgI2 (2.3 x 10-6 mmol) produced its positive inotropic effect indirectly by promoting both beta-adrenoreceptors and calcium entry through slow calcium channels because this effect could be blocked by propranolol (2.3 x 10-2 mmol - beta-adrenoreceptor blocker) or verapamil (4.3 x 10-3 mmol - slow calcium channel blocker).
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