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. 1992;88(2):95-104.
doi: 10.1007/BF01244815.

B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity

P Onali  1 , M C Olianas
Affiliations

B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity

P Onali et al. J Neural Transm Gen Sect. 1992.

Abstract

In homogenates of female rat anterior pituitary, the azepine derivative B-HT 920 inhibited the forskolin-stimulated adenylate cyclase activity with an EC50 value of 0.35 microM. In male rat anterior pituitary, B-HT 920 curtailed the stimulation of adenylate cyclase activity by vasoactive intestinal peptide with an EC50 of 0.20 microM. In synaptic plasma membranes of rat striatum, B-HT 920 significantly reduced basal adenylate cyclase activity with an EC50 of 0.68 microM. Both in pituitary and striatum, the B-HT 920 inhibition was counteracted by the dopamine (DA) D2 receptor antagonist 1-sulpiride, but not by the alpha 2-adrenergic antagonist yohimbine. These results indicate that B-HT 920 is capable of activating DA D2 receptors negatively coupled to adenylate cyclase activity.

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