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. 1992 Sep 16;187(2):744-50.
doi: 10.1016/0006-291x(92)91258-r.

de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite

N Surolia  1 , G Padmanaban
Affiliations

de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite

N Surolia et al. Biochem Biophys Res Commun. .

Abstract

The human malarial parasite, Plasmodium falciparum, has been found to synthesize heme de novo, despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite delta-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.

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