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. 1992 Sep;127(3):258-61.
doi: 10.1111/j.1365-2133.1992.tb00124.x.

Differential effect of griseofulvin on interferon-gamma-induced HLA-DR and intercellular adhesion molecule-1 expression of human keratinocytes

K Tamaki  1 , A Saitoh, N Yasaka
Affiliations

Differential effect of griseofulvin on interferon-gamma-induced HLA-DR and intercellular adhesion molecule-1 expression of human keratinocytes

K Tamaki et al. Br J Dermatol. 1992 Sep.

Abstract

Interferon-gamma (IFN-gamma) induces major histocompatibility complex (MHC) class II antigen and intercellular adhesion molecule-1 (ICAM-1) expression on human epidermal keratinocytes. Griseofulvin, an extensively used antifungal agent, has been used effectively in the treatment of lichen planus, in which keratinocytes express both HLA-DR and ICAM-1 antigens. In this study, we investigated the effect of griseofulvin on IFN-gamma-induced MHC class II antigen and ICAM-1 expression of keratinocytes, and demonstrated that griseofulvin decreased IFN-gamma-induced HLA-DR but not ICAM-1 expression.

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