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. 1992 Jun;40(6):1462-9.
doi: 10.1248/cpb.40.1462.

Development of a highly cardioselective ultra short-acting beta-blocker, ONO-1101

S Iguchi  1 , H Iwamura, M Nishizaki, A Hayashi, K Senokuchi, K Kobayashi, K Sakaki, K Hachiya, Y Ichioka, M Kawamura
Affiliations
Free article

Development of a highly cardioselective ultra short-acting beta-blocker, ONO-1101

S Iguchi et al. Chem Pharm Bull (Tokyo). 1992 Jun.
Free article

Abstract

A novel, highly cardioselective ultra short-acting beta-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in beta-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. This beta-blocking drug has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease and represents a major therapeutic advance in the treatment of heart disease.

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