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. 1992 Oct 3;340(8823):819-20.
doi: 10.1016/0140-6736(92)92687-b.

Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn

J P Kinsella  1 , S R Neish, E Shaffer, S H Abman
Affiliations

Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn

J P Kinsella et al. Lancet. .

Abstract

We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.

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