Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn
- PMID: 1357246
- DOI: 10.1016/0140-6736(92)92687-b
Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn
Abstract
We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.
Comment in
-
Simple method for monitoring concentration of inhaled nitric oxide.Lancet. 1992 Nov 7;340(8828):1167. doi: 10.1016/0140-6736(92)93201-w. Lancet. 1992. PMID: 1359248 No abstract available.
-
Inhaled nitric oxide for postoperative pulmonary hypertension in patients with congenital heart defects.Lancet. 1992 Dec 19-26;340(8834-8835):1545. doi: 10.1016/0140-6736(92)92796-i. Lancet. 1992. PMID: 1361626 No abstract available.
Similar articles
-
Inhaled nitric oxide in persistent pulmonary hypertension of the newborn.Lancet. 1992 Oct 3;340(8823):818-9. doi: 10.1016/0140-6736(92)92686-a. Lancet. 1992. PMID: 1357245
-
Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide.J Pediatr. 1993 Jul;123(1):103-8. doi: 10.1016/s0022-3476(05)81551-3. J Pediatr. 1993. PMID: 8320602
-
Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group.Pediatrics. 1998 Mar;101(3 Pt 1):325-34. doi: 10.1542/peds.101.3.325. Pediatrics. 1998. PMID: 9480993 Clinical Trial.
-
Controversies in the use of inhaled nitric oxide therapy in the newborn.Clin Perinatol. 1998 Mar;25(1):203-17. Clin Perinatol. 1998. PMID: 9523083 Review.
-
[Nitric oxide inhalation in newborn infants with pulmonary hypertension].Ned Tijdschr Geneeskd. 1998 Jan 17;142(3):123-7. Ned Tijdschr Geneeskd. 1998. PMID: 9557009 Review. Dutch.
Cited by
-
A pilot study on the kinetics of metabolites and microvascular cutaneous effects of nitric oxide inhalation in healthy volunteers.PLoS One. 2019 Aug 30;14(8):e0221777. doi: 10.1371/journal.pone.0221777. eCollection 2019. PLoS One. 2019. PMID: 31469867 Free PMC article.
-
Nitric oxide: Clinical applications in critically ill patients.Nitric Oxide. 2022 Apr 1;121:20-33. doi: 10.1016/j.niox.2022.01.007. Epub 2022 Feb 2. Nitric Oxide. 2022. PMID: 35123061 Free PMC article. Review.
-
Pulmonary Delivery of Therapeutic and Diagnostic Gases.J Aerosol Med Pulm Drug Deliv. 2018 Apr;31(2):78-87. doi: 10.1089/jamp.2017.1431. Epub 2018 Feb 16. J Aerosol Med Pulm Drug Deliv. 2018. PMID: 29451844 Free PMC article.
-
Inhaled nitric oxide for pulmonary hypertension after repair of exomphalos.Arch Dis Child. 1993 Nov;69(5 Spec No):518-20. doi: 10.1136/adc.69.5_spec_no.518. Arch Dis Child. 1993. PMID: 8285756 Free PMC article.
-
Can nitric oxide-based therapy prevent bronchopulmonary dysplasia?Clin Perinatol. 2012 Sep;39(3):613-38. doi: 10.1016/j.clp.2012.06.011. Clin Perinatol. 2012. PMID: 22954273 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources