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. 1976 Nov;20(2):441-5.
doi: 10.1128/JVI.20.2.441-445.1976.

Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo

H Berger, D Pardoll

Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo

H Berger et al. J Virol. 1976 Nov.

Abstract

T4 heteroduplex heterozygotes are lost selectively after prolonged incubation of phage-infected Escherichia coli cells under nonreplicating conditions. The loss of heterozygosity occurs for four out of six rII sites tested and is not dependent upon T4 v gene function. The results are interpreted to indicate the existence of a base-specific system for the recognition of mismatched bases in intracellular DNA.

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