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. 1958 Sep;13(3):308-14.
doi: 10.1111/j.1476-5381.1958.tb00908.x.

Pharmacological properties of betabeta-di-methyl-acryloylcholine and some other beta-substituted acryloylcholines

B HOLMSTEDT, V P WHITTAKER

Pharmacological properties of betabeta-di-methyl-acryloylcholine and some other beta-substituted acryloylcholines

B HOLMSTEDT et al. Br J Pharmacol Chemother. 1958 Sep.

Abstract

The mammalian pharmacology of a new naturally occurring ester of choline, betabeta-dimethylacryloylcholine (DMAC), has been studied, mainly in the cat, together with that of two synthetic beta-substituted acryloylcholines, crotonoylcholine and pent-2-enoylcholine. Comparisons have been made with the reduced form of DMAC, isovalerylcholine, with another naturally ocurring beta-substituted acryloylcholine, murexine (urocanoylcholine), and with suxamethonium. DMAC has been shown to be a ganglion stimulating and neuromuscular blocking agent generally similar, in potency and properties, to murexine. It is also a powerful respiratory stimulant. The other unsaturated esters behaved similarly but were less potent.

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