Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene (Gnt-1) to chromosome 1 by restriction fragment length variations
- PMID: 1359870
- DOI: 10.1007/BF00569325
Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene (Gnt-1) to chromosome 1 by restriction fragment length variations
Abstract
Restriction endonuclease fragment length variations (RFLVs) were detected by using a rat cDNA probe for the bilirubin UDP-glucuronosyltransferase (UDPGT) gene between two mouse strains, 129/Sv and MOL-MIT. RFLVs of the gene were found by EcoRI and PvuII digestions. From linkage analyses of the three-point cross test using Elo and En-1 as marker genes, the bilirubin UDPGT gene was mapped at position 37 on chromosome 1. Bilirubin and phenol UDPGTs have been suggested to be expressed by a single gene by alternative splicing in human and rat. The mouse bilirubin UDPGT gene was named Gnt-1.
Similar articles
-
Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations.Biochem Genet. 1995 Apr;33(3-4):111-22. doi: 10.1007/BF00557949. Biochem Genet. 1995. PMID: 7677729
-
[Genetic defect of the hyperbilirubinemic Gunn rat, a model for Crigler-Najjar syndrome type I].Nihon Rinsho. 1993 Feb;51(2):501-6. Nihon Rinsho. 1993. PMID: 8096554 Review. Japanese.
-
Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice.Genomics. 1991 Oct;11(2):309-16. doi: 10.1016/0888-7543(91)90137-4. Genomics. 1991. PMID: 1685137
-
Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript.Biochem Biophys Res Commun. 1990 May 31;169(1):260-4. doi: 10.1016/0006-291x(90)91462-2. Biochem Biophys Res Commun. 1990. PMID: 2112380
-
Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.Toxicol Appl Pharmacol. 2015 Nov 15;289(1):124-32. doi: 10.1016/j.taap.2015.08.018. Epub 2015 Sep 2. Toxicol Appl Pharmacol. 2015. PMID: 26342858 Free PMC article. Review.
Cited by
-
Mouse homologues of human hereditary disease.J Med Genet. 1994 Jan;31(1):1-19. doi: 10.1136/jmg.31.1.1. J Med Genet. 1994. PMID: 8151633 Free PMC article. Review.
-
Molecular chaperones, cochaperones, and ubiquitination/deubiquitination system: involvement in the production of high quality spermatozoa.Biomed Res Int. 2014;2014:561426. doi: 10.1155/2014/561426. Epub 2014 Jun 19. Biomed Res Int. 2014. PMID: 25045686 Free PMC article. Review.
-
Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations.Biochem Genet. 1995 Apr;33(3-4):111-22. doi: 10.1007/BF00557949. Biochem Genet. 1995. PMID: 7677729
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases
Research Materials