doi: 10.1016/0922-4106(92)90164-q.
Visualization of dopamine D3-like receptors in human brain with [125I]epidepride
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- PMID: 1359976
- DOI: 10.1016/0922-4106(92)90164-q
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Visualization of dopamine D3-like receptors in human brain with [125I]epidepride
Eur J Pharmacol.
.
Abstract
In sections of human brain containing the striatum (caudate, nucleus, putamen, nucleus accumbens) the competition for binding of [125I]epidepride by compounds with differing selectivity for dopamine D2 and D3 receptors was examined. Domperidone showed higher affinity for D2-like than D3-like sites whereas 7-OH-DPAT (7-hydroxy-2-(N,N-di-n-propylamino)tetralin) and quinpirole demonstrated the reverse selectivity. The pattern of [125I]epidepride binding in the presence of a high concentration of domperidone was negligible in the dorsal striatum but indicated islands of dense binding to D3-like receptors in the nucleus accumbens and ventral putamen.
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