Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Sep;8(3):355-8.

Hemopoietic reconstitution obtained in F1 hybrids by grafting of parental marrow cells

H von Boehmer, J Sprent, M Nabholz
  • PMID: 136073

Hemopoietic reconstitution obtained in F1 hybrids by grafting of parental marrow cells

H von Boehmer et al. Transplant Proc. 1976 Sep.

Abstract

T-cell tolerance to CML and MLR determinants in tetraparental bone marrow chimeras, prepared by injecting lethally x-irradiated F1 hybrids with bone marrow cells from both parental strains, is most likely due to clonal deletion. Tolerance to CML, but not to the host's MLR, determinants is observed when lethally x-irradiated F1 hybrids are repopulated with bone marrow from one parental strain only. The results demonstrate that removal of T cells from donor cells, as well as exclusion of a HVG reaction, make it possible to transplant bone marrow between allogeneic individuals.

PubMed Disclaimer

Publication types