The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL)
- PMID: 136099
- DOI: 10.1007/BF00286943
The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL)
Abstract
Platelets were suggested to play a specific role in the haematogenous spread of experimental tumours. To test this hypothesis mice were treated with various inhibitors or platelet function (acetyl-salicylic acid, RA 233, bencyclan-, cyproheptadine). The effect of treatment on the development of lung colonies after i.v. tumour cell injection as well as on the formation of spontaneous metastases from the solid Lewis-lung carcinoma was evaluated. A significant increase of lung colonies after pretreatment with the platelet aggregation inhibitors was found. The effect of long term treatment on spontaneous metastasis formation gave equivocal results. The present investigations do not support the importance of the integrity of platelet function as a prerequisite for metastasis formation.
Similar articles
-
Study of platelet aggregation in vivo: II. Effect of bencyclan on circulating metastatic tumor cells.J Med. 1977;8(1):53-6. J Med. 1977. PMID: 267156
-
Platelet aggregation inhibitors in the prevention of metastasis in neoplastic disease: a review of experimental and clinical investigations.J Med. 1981;12(1):15-33. J Med. 1981. PMID: 6943264 No abstract available.
-
Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors.Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 May 3;86(1):109-111. doi: 10.1007/BF00304941. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976. PMID: 132024
-
[Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results].Laryngol Rhinol Otol (Stuttg). 1983 Dec;62(12):578-85. Laryngol Rhinol Otol (Stuttg). 1983. PMID: 6369051 Review. German.
-
Antiplatelet pyrimido-pyrimidines and metastasis.Cancer Treat Rev. 1985 Dec;12(4):221-34. doi: 10.1016/0305-7372(85)90006-4. Cancer Treat Rev. 1985. PMID: 3009013 Review.
Cited by
-
Effect of ditazole, an inhibitor of platelet aggregation, on a metastasizing tumour in mice.Br J Cancer. 1978 Jan;37(1):126-9. doi: 10.1038/bjc.1978.18. Br J Cancer. 1978. PMID: 23140 Free PMC article. No abstract available.
-
Tumor-induced platelet aggregation and growth promoting factors as determinants for successful tumor metastasis.Clin Exp Metastasis. 1986 Jan-Mar;4(1):25-33. doi: 10.1007/BF00053470. Clin Exp Metastasis. 1986. PMID: 3698366
-
Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo.J Clin Invest. 1988 Apr;81(4):1012-9. doi: 10.1172/JCI113411. J Clin Invest. 1988. PMID: 3280598 Free PMC article.
-
Role of plasma, platelets, and endothelial cells in tumor metastasis.Cancer Metastasis Rev. 1984;3(2):99-114. doi: 10.1007/BF00047657. Cancer Metastasis Rev. 1984. PMID: 6386144 Review.
-
Inhibition of tumor cell arrest in lungs by antimetastatic chitin heparinoid.Jpn J Cancer Res. 1990 May;81(5):506-13. doi: 10.1111/j.1349-7006.1990.tb02599.x. Jpn J Cancer Res. 1990. PMID: 2116400 Free PMC article.