Hippocampal opioid peptides and seizures
- PMID: 1361330
Hippocampal opioid peptides and seizures
Abstract
We have employed a molecular biological approach to study the dynamic status of hippocampal opioid peptides in response to seizures elicited by different experimental models, such as electroconvulsive shocks (ECS) and amygdaloid kindling. Both ECS- and kindling-induced seizures triggered an initial large release of enkephalin and dynorphin, but produced opposite long-term effects on the biosynthesis of these two peptides, an increase of enkephalin, and a drastic decrease of dynorphin. Electrical stimulation of the perforant pathway produced differential changes of enkephalin and dynorphin, which were identical to those of ECS and kindling. This finding confirmed our hypothesis that the perforant pathway was responsible for the mediation of ECS- and kindling-induced changes in opioid peptide turnover. Strongest evidence indicating a role for opioid peptides in mediating the expression of seizure-related behaviors was found using the kainic acid model, where we saw that hippocampal enkephalin was essential to the expression of kainic acid-induced wet dog shakes (a preconvulsive shaking behavior). Furthermore, it was found that the granular-mossy fiber pathway of the ventral, but not the dorsal, hippocampus was essential for the expression of this shaking behavior. However, destruction of the granular-mossy fiber pathway potentiated the seizures and hippocampal cell loss induced by kainic acid. This unexpected, yet extremely interesting, finding not only distinguished the roles of the granular-mossy fiber pathway in mediating wet dog shakes vs. convulsive seizures, but also challenged the dogma that this granular-mossy fiber pathway is essential for the expression of limbic seizures.
Similar articles
-
Modulation of opioid peptide metabolism by seizures: differentiation of opioid subclasses.NIDA Res Monogr. 1986;71:89-101. NIDA Res Monogr. 1986. PMID: 3025738
-
Seizure-induced alterations in the metabolism of hippocampal opioid peptides suggest opioid modulation of seizure-related behaviors.NIDA Res Monogr. 1988;82:48-66. NIDA Res Monogr. 1988. PMID: 2899842 Review.
-
Interictal behavioral disturbances: a search for molecular substrates.Epilepsy Res Suppl. 1992;9:341-9; discussion 350. Epilepsy Res Suppl. 1992. PMID: 1337448 Review.
-
Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling.Hippocampus. 2001;11(6):615-25. doi: 10.1002/hipo.1076. Hippocampus. 2001. PMID: 11811655
-
Limbic epileptogenicity, cell loss and axonal reorganization induced by audiogenic and amygdala kindling in wistar audiogenic rats (WAR strain).Neuroscience. 2004;125(3):787-802. doi: 10.1016/j.neuroscience.2004.01.042. Neuroscience. 2004. PMID: 15099692
Cited by
-
Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy.Br J Pharmacol. 2000 Sep;131(2):203-12. doi: 10.1038/sj.bjp.0703562. Br J Pharmacol. 2000. PMID: 10991912 Free PMC article.
-
Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.J Neurosci. 2015 Jan 28;35(4):1723-38. doi: 10.1523/JNEUROSCI.0820-14.2015. J Neurosci. 2015. PMID: 25632146 Free PMC article.
-
Neuro-Behavioral Profile and Toxicity of the Essential Oil of Dorema ammoniacum Gum as an Anti-seizure, Anti-nociceptive, and Hypnotic Agent with Memory-enhancing Properties in D-Galactose Induced Aging Mice.Iran J Pharm Res. 2020 Summer;19(3):110-121. doi: 10.22037/ijpr.2020.113738.14458. Iran J Pharm Res. 2020. PMID: 33680015 Free PMC article.
-
Anticonvulsant Effects of the Hydroalcoholic Extract of Alpinia officinarum Rhizomesin Mice: Involvement of Benzodiazepine and Opioid Receptors.J Epilepsy Res. 2017 Jun 30;7(1):33-38. doi: 10.14581/jer.17006. eCollection 2017 Jun. J Epilepsy Res. 2017. PMID: 28775953 Free PMC article.
-
Effect of Hydroalcoholic Extract of Stachys lavandulifolia on Pentylenetetrazole-induced Seizures in Male Mice: The Role of GABAergic and Opioidergic Systems.Basic Clin Neurosci. 2022 Jan-Feb;13(1):107-116. doi: 10.32598/bcn.2021.2299.1. Epub 2022 Jan 1. Basic Clin Neurosci. 2022. PMID: 36589024 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical