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. 1992 Nov;45(11):1733-7.
doi: 10.7164/antibiotics.45.1733.

Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. II. Biological activities

K Tanzawa  1 , M Ishii, T Ogita, K Shimada
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Free article

Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. II. Biological activities

K Tanzawa et al. J Antibiot (Tokyo). 1992 Nov.
Free article

Abstract

Matlystatin A, the main component of matlystatins, inhibits 92 kDa and 72 kDa typeIV collagenases with IC50 values of 0.3 microM and 0.56 microM, respectively, while 7- to 11-fold greater concentrations are required to inhibit thermolysin and aminopeptidase M. The inhibition is reversible and competitive with respect to gelatin. It inhibits the invasion of basement membrane Matrigel by human fibrosarcoma HT1080 dose-dependently with an IC50 value of 21.6 microM.

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