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. 1992 Dec:161:855-6.
doi: 10.1192/bjp.161.6.855.

Clozapine rechallenge after an episode of 'neuroleptic malignant syndrome'

M Weller  1 , J Kornhuber
Affiliations

Clozapine rechallenge after an episode of 'neuroleptic malignant syndrome'

M Weller et al. Br J Psychiatry. 1992 Dec.

Abstract

Nine out of 4044 patients admitted to our institution between 1987 and 1990 suffered an episode of NMS. Neuroleptic rechallenge using clozapine for persisting psychiatric illness was tolerated by eight patients. Clozapine was discontinued in one older, high-risk patient because recurrence of NMS was anticipated. Clozapine should be considered a drug of choice for psychotic patients with a history of NMS.

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Comment in

  • Neuroleptic rechallenge after neuroleptic malignant syndrome.
    Giacardi-Paty M, Bottai T, Pujalte D, Lainey E, Petit P. Giacardi-Paty M, et al. Br J Psychiatry. 1993 Jul;163:121-2. doi: 10.1192/bjp.163.1.121a. Br J Psychiatry. 1993. PMID: 8102585 No abstract available.
  • Clozapine and NMS.
    Buckley PF, Meltzer HY. Buckley PF, et al. Br J Psychiatry. 1993 Apr;162:566. doi: 10.1192/bjp.162.4.566a. Br J Psychiatry. 1993. PMID: 8329060 No abstract available.

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