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. 1959 Jan 30;129(3344):275-6.
doi: 10.1126/science.129.3344.275.

Significance of mitochondria for porphyrin and heme biosynthesis

S SANO, S INOUE, Y TANABE, C SUMIYA, S KOIKE

Significance of mitochondria for porphyrin and heme biosynthesis

S SANO et al. Science. .

Abstract

It is concluded that mitochondria are involved in three steps of porphyrin and heme biosynthesis-first, in the formation of delta-aminolevulinic acid from glycine and active succinate; second, in the synthesis of protoporphyrin; third, in the incorporation of iron into the porphyrin ring-that is, in heme formation.

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