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Review
. 1976 Aug;60(8):1127-39.

Pharmacology of antitumor agents from higher plants

S M Sieber, J A Mead, R H Adamson
  • PMID: 136296
Review

Pharmacology of antitumor agents from higher plants

S M Sieber et al. Cancer Treat Rep. 1976 Aug.

Abstract

Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.

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