Isolation of a new human pseudogene for proliferating cell nuclear antigen
- PMID: 1363247
Isolation of a new human pseudogene for proliferating cell nuclear antigen
Abstract
A new gene, which cross-hybridized with a rat PCNA cDNA probe, has been isolated from a human genomic cosmid library. A comparison of the gene with the human PCNA cDNA revealed 71% homology for the nucleotide sequences. This gene completely lacks introns and has traces of a polyA tail which the messenger RNA of the active gene retains. These facts indicate that this gene was generated by the reverse-transcription of a processed RNA for PCNA and exists as a PCNA pseudogene in the human genome.
Similar articles
-
Nucleotide sequence of a human genomic DNA fragment containing the PCNA pseudogene and its localization on chromosome 4.Tokai J Exp Clin Med. 1994 Sep;19(1-2):1-5. Tokai J Exp Clin Med. 1994. PMID: 7660377
-
Cloning, sequencing, and chromosomal localization of two tandemly arranged human pseudogenes for the proliferating cell nuclear antigen (PCNA).Mamm Genome. 1996 Dec;7(12):906-8. doi: 10.1007/s003359900266. Mamm Genome. 1996. PMID: 8995762
-
Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen.Nucleic Acids Res. 1991 May 11;19(9):2403-10. doi: 10.1093/nar/19.9.2403. Nucleic Acids Res. 1991. PMID: 1674997 Free PMC article.
-
DNA methylation is not involved in growth regulation of gene expression of proliferating cell nuclear antigen.Exp Cell Res. 1993 Oct;208(2):479-84. doi: 10.1006/excr.1993.1269. Exp Cell Res. 1993. PMID: 7690711
-
Growth regulation of the PCNA gene.J Cell Sci. 1991 Apr;98 ( Pt 4):433-6. doi: 10.1242/jcs.98.4.433. J Cell Sci. 1991. PMID: 1677646 Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous