Na+/K(+)-ATPase as an effector of synaptic transmission
- PMID: 1363911
- DOI: 10.1016/0197-0186(92)90121-7
Na+/K(+)-ATPase as an effector of synaptic transmission
Abstract
Evidence is presented in support of the hypothesis that transmitter monoamines can exert their post-synaptic effects by stimulation or inhibition of Na+/K(+)-ATPase in neuronal or glial cell plasma membranes. Stimulation of electrogenic sodium pumping, causing a hyperpolarization with an increase in membrane resistance, could account for the depression of neuronal spontaneous firing and the signal/noise enhancing actions of these amines. Conversely, inhibition of an electrogenic sodium pump in neuronal plasma membranes would lead to depolarization and enhanced excitability.