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. 1992;79(2):131-7.

(-)Deprenyl (selegiline) is devoid of amphetamine-like behavioural effects in rats

J Tímár  1 , B Knoll, J Knoll
Affiliations
  • PMID: 1363925

(-)Deprenyl (selegiline) is devoid of amphetamine-like behavioural effects in rats

J Tímár et al. Acta Physiol Hung. 1992.

Abstract

Central effects of high dose (-)deprenyl (50-100 mg/kg sc) was compared to that of (+)deprenyl and (+/-)amphetamine (AM). (+)Deprenyl and AM induced stereotyped behaviour, increased spontaneous motility in smaller and decreased it in higher doses, inhibited escape behaviour and shuttle-box avoidance. (-)Deprenyl failed to possess any of these effects, providing further evidence that AM-type metabolites have no share in the action of (-)deprenyl.

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