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Review
. 1992;46(10):465-71.
doi: 10.1016/0753-3322(92)90004-q.

Present status of agonistic and antagonistic analogs of LH-RH in the treatment of advanced prostate cancer

A V Schally  1 , A M Comaru-Schally, D Gonzalez-Barcena
Affiliations
Review

Present status of agonistic and antagonistic analogs of LH-RH in the treatment of advanced prostate cancer

A V Schally et al. Biomed Pharmacother. 1992.

Abstract

The methods for treatment of advanced prostate cancer, based on the agonistic analogs of LH-RH were reviewed. New therapeutic approaches utilizing antagonistic analogs of LH-RH such as SB-75 (Cetrorelix) have been described. Analogs of LH-RH chemically linked to various cytotoxic radicals are also being developed. Combinations of LH-RH agonists or antagonists with superactive somatostatin analogues such as Octastatin (RC-160) or with bombesin/GRP antagonists are being investigated in order to delay or prevent the relapse and improve the therapy for prostate cancer.

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