Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1959 May 1;109(5):463-74.
doi: 10.1084/jem.109.5.463.

Studies on the adjuvant action of bacterial endotoxins on antibody formation. III. Histologic response of the rabbit spleen to a single injection of a purified protein antigen

P A WARD, A G JOHNSON, M R ABELL

Studies on the adjuvant action of bacterial endotoxins on antibody formation. III. Histologic response of the rabbit spleen to a single injection of a purified protein antigen

P A WARD et al. J Exp Med. .

Abstract

Histologic changes occurring in the rabbit spleen during the primary response to intravenous injection of bovine gamma globulin alone and in combination with bacterial endotoxin have been described. The predominant morphologic changes associated with antibody formation in animals that received antigen alone were confined to the follicular areas of the spleen. Only minimal changes were seen in the red pulp. No new cellular types appeared following endotoxin stimulus. Rather, a profound augmentation of events observed following a single injection of bovine gamma globulin alone appears to account for the higher levels of antibody incited by this adjuvant. The cell type important in antibody formation under these conditions appeared to be a modified reticular cell. Plasma cells were not part of the cellular reaction. A hypothesis describing the primary antibody response is presented.

PubMed Disclaimer

References

    1. J Lab Clin Med. 1953 Oct;42(4):598-620 - PubMed
    1. Am J Hyg. 1954 Mar;59(2):150-6 - PubMed
    1. J Exp Med. 1955 Jul 1;102(1):83-104 - PubMed
    1. J Immunol. 1950 Oct;65(4):359-67 - PubMed
    1. J Immunol. 1954 Jan;72(1):45-51 - PubMed