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. 1992 Nov-Dec;2(6):329-32.

Does C-reactive protein modulate T-lymphocyte function in methotrexate-treated rheumatoid arthritis patients?

K E Wiktorowicz  1 , J K Lacki, P Błazczak, J Cofta, S H Mackiewicz
Affiliations
  • PMID: 1364169

Does C-reactive protein modulate T-lymphocyte function in methotrexate-treated rheumatoid arthritis patients?

K E Wiktorowicz et al. J Investig Allergol Clin Immunol. 1992 Nov-Dec.

Abstract

Thirty-four patients with rheumatoid arthritis were treated with oral methotrexate for 6 months. Methotrexate was given as a single weekly dose of 7.5-10 mg. A correlation between serum concentration of CRP and proportion of CD8+ lymphocytes in peripheral blood was found in this group of patients. This correlation can be described by a linear regression equation. According to the results obtained, CRP suppresses lymphocyte function in patients with RA. This is the consequence of the stimulating effect on suppressor mechanisms.

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