Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Mar;102(3):563-4.
doi: 10.1111/j.1476-5381.1991.tb12211.x.

Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation

D A Craig  1 , D E Clarke
Affiliations

Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation

D A Craig et al. Br J Pharmacol. 1991 Mar.

Abstract

The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3 microM), but not ondansetron (5 microM). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Pharmacol Exp Ther. 1990 Mar;252(3):1378-86 - PubMed
    1. Eur J Clin Pharmacol. 1990;38(2):161-4 - PubMed
    1. Br J Pharmacol Chemother. 1958 Dec;13(4):444-57 - PubMed
    1. Neuropharmacology. 1986 Jun;25(6):563-76 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Dec;83(24):9799-803 - PubMed

Publication types

LinkOut - more resources