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. 1991 Mar;102(3):563-4.
doi: 10.1111/j.1476-5381.1991.tb12211.x.

Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation

D A Craig  1 , D E Clarke
Affiliations

Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation

D A Craig et al. Br J Pharmacol. 1991 Mar.

Abstract

The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3 microM), but not ondansetron (5 microM). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.

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