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. 1959 Mar;14(1):108-11.
doi: 10.1111/j.1476-5381.1959.tb00935.x.

The effects of reserpine and other agents upon leptazol convulsions in mice

A W LESSIN, M W PARKES

The effects of reserpine and other agents upon leptazol convulsions in mice

A W LESSIN et al. Br J Pharmacol Chemother. 1959 Mar.

Abstract

Reserpine and tetrabenazine reduced the survival time of mice infused with leptazol. This effect was antagonized by pretreatment with iproniazid. The survival time of iproniazid-treated mice was prolonged by 5-hydroxytryptophan but not by 3:4-dihydroxyphenylalanine. These findings suggest a relation between leptazol sensitivity and brain levels of 5-hydroxytryptamine.

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