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Review
. 1992 Feb;1(1):3-10.

Application of crystallography to the design of antiviral agents

M G Rossmann  1 , M A McKinlay
Affiliations
  • PMID: 1365526
Review

Application of crystallography to the design of antiviral agents

M G Rossmann et al. Infect Agents Dis. 1992 Feb.

Abstract

A historical review of x-ray crystallography introduces basic concepts and describes the potential of this science to the rational design of antiviral agents. Following a brief introduction to the study of antiviral compounds that inhibit early stages of rhino- and enteroviral infections, the impact of structural studies on rational drug design is discussed in relation to known viral structures.

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