Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992;109(3):377-8.
doi: 10.1007/BF02245887.

Hypouricemic effect of zuclopenthixol: a potential marker of drug compliance?

M Bloch  1 , E Gur, A Y Shalev
Affiliations

Hypouricemic effect of zuclopenthixol: a potential marker of drug compliance?

M Bloch et al. Psychopharmacology (Berl). 1992.

Abstract

Twelve newly-admitted psychotic patients were treated with clinical doses of zuclopenthixol (ZPT). Plasma uric acid (PUA) was measured before and during treatment. ZPT reduced PUA in all the patients by an average of 29.6% (P < 0.0001). PUA levels during treatment correlated with those obtained before treatment (R = 0.871, P < 0.0002). PUA returned to initial levels on discontinuation of treatment. Uric acid excretion increased during treatment. It is concluded that ZPT is a potent uricosuric agent, capable of producing persistent hypouricemia while administered. Such hypouricemia might be a useful indicator of drug compliance.

PubMed Disclaimer

References

    1. J Clin Psychiatry. 1989 Nov;50(11):424-7 - PubMed
    1. Ann Intern Med. 1979 Jul;91(1):44-7 - PubMed
    1. Nephron. 1988;48(1):71-3 - PubMed
    1. Clin Pharmacol Ther. 1990 Dec;48(6):652-64 - PubMed
    1. Clin Pharmacokinet. 1986 Jan-Feb;11(1):36-61 - PubMed

LinkOut - more resources