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. 1990 Jan;5(1):1-8.
doi: 10.1007/BF01569600.

Characterization of peptidyl-nucleoside antifungal antibiotics from fermentation broth

R Cooper  1 , P Das, C Federbush, R Mierzwa, M Patel, B Pramanik, I Truumees
Affiliations

Characterization of peptidyl-nucleoside antifungal antibiotics from fermentation broth

R Cooper et al. J Ind Microbiol. 1990 Jan.

Abstract

Characterization of sinefungin related antifungal antibiotics from fermentation broth was accomplished by coupling photodiode array (PDA) detection to high performance liquid chromatography (HPLC). From the combined HPLC-PDA evaluation of broth filtrate, we detected five sinefungin related components. Fast atom bombardment (FAB) mass spectroscopic evaluations, mass-analysed ion kinetic energy spectra (MIKES) and collision activated (CA) MIKES of these components confirmed their respective identities. Our findings from the combination of HPLC photodiode array acquisition and FAB-mass spectrometry suggest we have detected the presence of a previously unreported sinefungin analogue.

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