Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis
- PMID: 1366623
- DOI: 10.1016/0167-7799(90)90170-3
Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis
Abstract
The expression of genes encoding enzymes involved in antibiotic and other secondary metabolite biosynthesis is down-regulated by easily assimilable phosphate, carbon and nitrogen sources. Phosphate control of antibiotic production appears to act at the transcriptional level by a mechanism similar to that involved in control of phosphatases and other phosphate-regulated enzymes. A phosphate control (PC) sequence, strikingly similar to the phosphate control (pho) boxes of many bacterial genes, has been isolated from the phosphate regulated promoter that controls biosynthesis of the antibiotic candicidin, and characterized. From computer analysis of sequence data, PC sequences appear to be associated with promoter regions of several phosphate-controlled antibiotic biosynthetic genes.
Similar articles
-
Cloning and characterization of a phosphate-regulated promoter involved in phosphate control of candicidin biosynthesis.Gene. 1989 Jun 30;79(1):47-58. doi: 10.1016/0378-1119(89)90091-7. Gene. 1989. PMID: 2550329
-
A Hierarchical Network of Four Regulatory Genes Controlling Production of the Polyene Antibiotic Candicidin in Streptomyces sp. Strain FR-008.Appl Environ Microbiol. 2020 Apr 17;86(9):e00055-20. doi: 10.1128/AEM.00055-20. Print 2020 Apr 17. Appl Environ Microbiol. 2020. PMID: 32086301 Free PMC article.
-
Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families.Microbiology (Reading). 2015 Mar;161(Pt 3):539-52. doi: 10.1099/mic.0.000033. Epub 2015 Jan 9. Microbiology (Reading). 2015. PMID: 25575546
-
The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis.J Antibiot (Tokyo). 2017 May;70(5):534-541. doi: 10.1038/ja.2017.19. Epub 2017 Mar 15. J Antibiot (Tokyo). 2017. PMID: 28293039 Review.
-
Candicidin biosynthesis in Streptomyces griseus.Appl Microbiol Biotechnol. 2003 Feb;60(6):633-42. doi: 10.1007/s00253-002-1163-9. Epub 2002 Dec 18. Appl Microbiol Biotechnol. 2003. PMID: 12664141 Review.
Cited by
-
Genomic analysis reveals the major driving forces of bacterial life in the rhizosphere.Genome Biol. 2007;8(9):R179. doi: 10.1186/gb-2007-8-9-r179. Genome Biol. 2007. PMID: 17784941 Free PMC article.
-
Reciprocal Regulation of GlnR and PhoP in Response to Nitrogen and Phosphate Limitations in Saccharopolyspora erythraea.Appl Environ Microbiol. 2015 Oct 30;82(1):409-20. doi: 10.1128/AEM.02960-15. Print 2016 Jan 1. Appl Environ Microbiol. 2015. PMID: 26519391 Free PMC article.
-
Systematic Analysis of the Lysine Crotonylome and Multiple Posttranslational Modification Analysis (Acetylation, Succinylation, and Crotonylation) in Candida albicans.mSystems. 2021 Jan 26;6(1):e01316-20. doi: 10.1128/mSystems.01316-20. mSystems. 2021. PMID: 33500332 Free PMC article.
-
Effect of phosphate concentration on production of tetrodotoxin by Alteromonas tetraodonis.Appl Environ Microbiol. 1993 Nov;59(11):3981-3. doi: 10.1128/aem.59.11.3981-3983.1993. Appl Environ Microbiol. 1993. PMID: 8285702 Free PMC article.
-
Effects of replacement of promoters and modification of the leader peptide region of the amy gene of Streptomyces griseus on synthesis and secretion of alpha-amylase by Streptomyces lividans.Mol Gen Genet. 1991 Dec;231(1):88-96. doi: 10.1007/BF00293826. Mol Gen Genet. 1991. PMID: 1753948
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical